Nebelivka brings forth transdisciplinary research in the development of new models of cooperation across the Built Environment, Forestry, and Agriculture sectors towards establishing new paradigms for local and global material flows. Towards the development of a biocompatible, regenerative material economy, the featured project develops materials from biowaste and silvicultural practices, preserving and enabling endangered indigenous and vernacular techniques by integrating with emerging biosciences. Biomaterial systems from agricultural waste and forest byproducts incorporate fabrication methods declared by UNESCO as ‘intangible cultural heritage of humanity’ that may be at risk. The structural, mechanical and environmental properties are enhanced with novel CAD-CAM fabrication, advanced energy, biochemical and bacterial processes for healthy indigo coloration. Integration of AI processes in the selection of species forges a new partnership model for designers to collaborate with forest managers and silviculture practitioners to cull plant-based materials while bolstering the biodiversity and climate resiliency of regional ecosystems.